Van de Ven Double Ends The Toffees' Run at New Home Ground
Micky van de Ven emerged as the initial backline player to score two goals in a English top-flight match for Tottenham since the Belgian defender in March 2013.
At a glance
The Spurs defender nods into the net twice in opening period
Everton's Jake O'Brien has equalizer disallowed after VAR review
Senegalese midfielder scores final goal in dying moments
The defeat is Everton's first at their new ground
Micky van de Ven scored on two occasions as Spurs prolonged their winning streak on the road in the Premier League and handed the Toffees their initial loss at their new home.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left their historic home behind after more than a century at the conclusion of the previous campaign.
But Spurs captain the Dutchman struck twice from corners in the first half to place their impressive record at risk, and they were failed to turn it around before the midfielder - assisted by former Toffees attacker the Brazilian - headed home a third to put the game to bed.
Jake O'Brien believed he had equalized the tally a short while after Van de Ven's first goal, directing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, meanwhile, failed to convert a handful of opportunities, while Vicario made a succession of excellent saves to ensure the London club went five away games unbeaten in the Premier League.
But the VAR intervened, instructing Craig Pawson to review the goal on the screen and the referee ruled that the winger and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
This victory elevates Thomas Frank's team up to third in the division, a handful of points off north London rivals and leaders the Gunners.
The Merseyside club remain in 14th position and are half a dozen points clear of the relegation zone.
Spurs breakdown: Van de Ven excels in duties at both ends of the field
After a drab weekday display in the European competition against the French side, where they managed a mere two shots on goal, Frank opted for Randal Kolo Muani in attack instead of ex-Everton forward the Brazilian.
The summer signing was unable to influence the game before being replaced for the substitute after 60 minutes on the pitch, but it emerged he proved unnecessary in the end.
Centre-back the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's opening strike came from a well-worked set-piece play, with the midfielder directing the ball back across the six-yard box for an unmarked the defender to head home.
And the captain - filling in as skipper in the Argentine's unavailability - notched his next goal in added time as he rose above the England keeper to head home.
The Dutchman was equally outstanding in defensive duties, combining effectively with Kevin Danso as the pair handled excellently with the 34 crosses thrown their way by Everton.
Toffees breakdown: Everton missing striker's instinct
Everton's new home had been a happy hunting ground, but it appears the freshness may have faded slightly and fans headed to the exits after Sarr's final goal for Spurs.
The break in Everton's winning streak at home will not be a massive worry for the manager, but their attacking woes are.
Beto and the other striker - the Toffees' two established centre-forwards - had netted only one league goal combined before Sunday's outing.
And they were unable to add to that poor record on a damp and dreary evening on Merseyside.
Beto's performance was summed up when he chose to overhead kick a golden opportunity from near the goal, even with having room and opportunity to reposition for a more conventional attempt that would have challenged Vicario.
The substitute, too, failed to make an impact after replacing Beto in the second half.
It was not for a lack of chance. Most of Everton's attacks came through the winger and the forward, who tirelessly delivered dangerous balls into the Tottenham box.
What next for these two sides?
Everton: The team head to the Stadium of Light in the top flight on early November at 8 PM.
Spurs: Spurs travel to St James' Park on late October for their next round League Cup match against Newcastle.